APPLICATION OF MODELLING AND SIMULATION APPROACHES TO PREDICT PHARMACOKINETICS OF THERAPEUTIC MONOCLONAL ANTIBODIES IN PEDIATRIC POPULATION

Application of Modelling and Simulation Approaches to Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies in Pediatric Population

Ethical regulations and limited paediatric participants are key challenges that contribute to a median delay of 6 years in paediatric mAb approval.To overcome these barriers, modelling and simulation methodologies have been adopted to design optimized paediatric clinical studies and reduce patient burden.The classical modelling approach in paediatr

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Advances in Detection Technologies for Pesticide Residues and Heavy Metals in Rice: A Comprehensive Review of Spectroscopy, Chromatography, and Biosensors

Pesticide residues and heavy metals, originating from diverse sources such as agricultural practices and industrial activities, pose substantial risks to human health and the ecological environment.For instance, residues of organophosphorus pesticides may damage the human nervous system, Coat Hooks while heavy metals such as mercury and cadmium acc

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Network pharmacology and experimental study of phenolic acids in salvia miltiorrhiza bung in preventing ischemic stroke

At present, the preventive effect of ischemic stroke is not ideal, and the preventive drugs are limited.Danshen, the dried root of Salvia miltiorrhiza Bge, is a Tree Bongs common medicinal herb in Traditional Chinese Medicine, which has been used for the treatment of cardiovascular diseases for many years.Phenolic Acids extracted from danshen, whic

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Oral health promotion programmes in the Balkan countries: Part II

Background/Aim: The aim of this study was to conduct a comparative analysis of the oral health promotion programmes in the Balkan countries, to compare key measures and activities in the implementation of the programme, and to analyse the results achieved after the implementation of the programme.Material and Methods: Data were obtained through an

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